Since patients with HIV/AIDS are living much longer with HAART therapy, HIV/AIDS has now become a part of the chronic disease burden, like hypertension and diabetes. Symptoms suggestive of cardiac disease represent a diagnostic and therapeutic challenge in clinical practice; Cardiologists are more frequently encountering this problem. South Africa has the worse HIV/AIDS epidemic but also the largest HIV management program. This means that clinicians and policy markers will face the worse challenge in dealing with the future occurrence of cardiovascular diseases. Unfortunately, that future burden of CDV among chronic HIV/AIDS cases in not yet well understood. The aim of this workshop is to provide an update on non-communicable diseases in patients with and without HIV infection.